سجل الآن

Vasodilating effect of Hypericum revolutum (Vahl) (Clusiaceae) methanol extract in rats

19/10/42 Purpose: To investigate the vasodilating effect of Hypericum revolutum Vahl (Clusiaceae) in rats.

Methods: H. revolutum aerial parts were extracted with methanol. The total methanol extract was fractionated with chloroform to yield fraction I. The remaining aqueous solution was chromatographed on Diaion HP-20 using water, 50 % methanol, and methanol to yield three fractions (II- IV). Total methanol extract and fractions I-IV were applied to phenylephrine-pre-contracted (10 μM) rat aortic rings at doses of 1, 3, and 10 μg/mL. Subsequent decreases in aortic tension were recorded by an isometric force transducer to evaluate the vasodilation. Column chromatography was utilized to separate the active components of the bioactive fraction.

Results: Remarkable decreases in aortic tension (p0.05) revealed that fraction I (3 and 10 μg/mL) produced a vasodilating effect, whereas fractions III and IV did not possess any substantial effect. Vasodilation induced by fraction I was endothelial-dependent because it was significantly (p0.05) blocked by endothelial denudation. Phytochemical inspection of fraction I led to the isolation of β-sitosterol (1), 1,7-dihydroxyxanthone (euxanthone) (2), and 2,3,4-tirmethoxy xanthone (3). Conclusion: Fraction I of the H. revolutum extract was responsible for its vasodilating effect. This fraction may be used as a possible anti-hypertensive preparation after in vivo testing and successful clinical trials.

other-researches

15/01/43

Kirenol: A promising bioactive metabolite from siegesbeckia species: A detailed review

اكتشف المزيد

20/07/42

Repurposing of Some Natural Product Isolates as SARS-COV-2 Main Protease Inhibitors via In Vitro Cell Free and Cell-Based Antiviral Assessments and Molecular Modeling Approaches

اكتشف المزيد

07/11/42

Nitric-Oxide-Mediated Vasodilation of Bioactive Compounds Isolated from Hypericum revolutum in Rat Aorta

اكتشف المزيد

15/12/42

Natural Products of the Fungal Genus Humicola: Diversity, Biological Activity, and Industrial Importance

اكتشف المزيد

12/10/42

Jojoba oil: An updated comprehensive review on chemistry, pharmaceutical uses, and toxicity

اكتشف المزيد

سياسة ملفات الارتباط

ايستخدم هذا الموقع ملفات تعريف الارتباط لتحسين تجربة المستخدم الخاصة بك. من خلال القبول والإغلاق عند زيارة الصفحة لأول مرة ، فإنك توافق على استخدامنا لملفات تعريف الارتباط